PFIZER INJECTABLES Epinephrine Prefilled Syringe 0.1 mg/mL Abboject Glass with Male Luer Lock Adapter 10 mL x 10/Pack (Rx)

Epinephrine Prefilled Syringe 0.1 mg/mL Abboject Glass with Male Luer Lock Adapter 10 mL is used in emergency medical situations to treat severe allergic reactions (anaphylaxis), cardiac arrest, and other conditions requiring immediate intervention. Epinephrine, also known as adrenaline, acts as a vasoconstrictor and bronchodilator, quickly increasing heart rate, blood pressure, and airway patency. The prefilled syringe ensures precise dosing and rapid administration, which is critical in life-threatening emergencies.

Epinephrine Prefilled Syringe, supplied by Pfizer Injectables, is designed for immediate and effective intervention in acute allergic reactions, including anaphylaxis, and for other emergency uses that require rapid cardiovascular support. The syringe is prefilled with a concentration of 0.1 mg/mL of epinephrine and is equipped with a Male Luer Lock Adapter for quick and secure connection to a compatible delivery device. Packaged in a convenient Abboject Glass system, these prefilled syringes come in 10 mL volumes with each box containing 10 syringes, ready for use in emergency medical settings.

Details and Features

Active Ingredient: Epinephrine
Concentration: 0.1 mg/mL
Volume: 10 mL per syringe
Packaging: 10 prefilled Abboject Glass syringes per pack
Adapter: Male Luer Lock for secure and quick attachment
Usage: Immediate response to anaphylaxis, asthma attacks, and other critical conditions requiring rapid cardiovascular action
Manufacturer: Pfizer Injectables

Mechanism of Action

Epinephrine acts as both an alpha and beta-adrenergic agonist. It stimulates alpha-adrenergic receptors, leading to vasoconstriction and an increase in blood pressure, essential in counteracting vasodilation and increased vascular permeability during anaphylactic shock. Concurrently, its action on beta-adrenergic receptors results in bronchodilation, alleviating respiratory distress, and enhances cardiac output by increasing heart rate and myocardial contractility. This combination of effects rapidly reverses symptoms of severe allergic reactions and supports cardiovascular stability.

Warnings

• Severe Hypertension: Patients with cardiovascular disorders should be monitored closely due to the risk of precipitating severe hypertension.
• Arrhythmias: Possibility of inducing cardiac arrhythmias or myocardial ischemia, particularly in patients with preexisting heart conditions.
• Hyperthyroid or Diabetic Individuals: Use cautiously; epinephrine can exacerbate symptoms of hyperthyroidism and antagonize the action of insulin.
• Pregnancy: Risk-benefit should be evaluated, although epinephrine should not be withheld in life-threatening situations.
• Extravasation Risk: Ensure proper injection technique and monitor for signs of extravasation that may cause localized tissue necrosis.

Side Effects

Common Side Effects:

• Palpitations or tachycardia
• Anxiety or nervousness
• Headache
• Tremors

Serious Side Effects:

• Severe hypertension or hypertensive crisis
• Acute myocardial infarction or angina in at-risk patients
• Cerebral hemorrhage in cases of significantly increased blood pressure
• Arrhythmias or cardiac arrest

Administration and Monitoring

Epinephrine Prefilled Syringe is intended for use by healthcare professionals trained in acute care settings and familiar with the management of anaphylaxis and other cardiovascular emergencies. Administration should be followed by continuous monitoring of cardiovascular and respiratory function, adjusting treatment as necessary to manage any adverse events. Equipment for emergency resuscitation and advanced cardiovascular support should be readily available wherever epinephrine administration occurs.